I’ve been working with SCOM since late 2007, first OpsMgr 2007, now SCOM 2012. I’ve mainly worked on the backend — design, engineering, custom MP creation, etc. — and always at large customers (1000+ servers). My current environment is only ~1500 servers and 20K desktops though.
I’m past the optimization stage, now I’m focused on how to take advantage of what SCOM (and System Center) provides. I want to WOW my management with useful data, stats, and visuals. I’m currently beginning to work with Live Maps as well and am excited to see what it brings to the SCOM experience.